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Garlic and ginger extracts modulated broiler chicks innate immune responses and enhanced multidrug resistant Escherichia coli O78 clearance
Faculty
Veterinary Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Gamal Abdelmoniem Mohamed Abedallah
Staff Zu Site
Abstract In Staff Site
Journal:
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES Elsevier
Volume:
Keywords :
Garlic , ginger extracts modulated broiler chicks
Abstract:
Administration of antibiotics as feed additives in broilers resulted in prompting of some undesirable effects such as the rising emergence of multi-drug resistant (MDR) bacteria, so scrutinizing for new alternatives like herbs is the up to date task for global health. This study was designed to determine the in-vitro antibacterial and ex-vivo immunomodulatory efficacy of garlic (Allium sativum) and ginger (Zingiber officinale) extracts post dietary supplementation for 900-one-day-old Sasso broiler chicks. The in-vivo protective actions of these extracts against avian pathogenic MDR Escherichia coli (E. coli) O78 challenge was evaluated after 21 days of extracts supplementation. Garlic extract exhibited broader antimicrobial spectra against MDR E. coli O78 and S. aureus isolates. Through the 21 days of garlic or ginger dietary supplementation, the chicks' innate immune response was modulated via various mechanisms including phagocytosis augmentation, bactericidal activity enhancement and nitric oxide (NO) production reduction, together with triggering the IL-1β, IL-6 and IFN-γ cytokines expression levels in comparison with the non-supplemented chicks. It is tempting to speculate that protection against pathogenic E. coli O78 challenge was high in chicks supplemented with each individual extract with severe reduction in the bacterial colony forming units in chicks' vital organs that confirm the extracts immunomodulatory activity and provide a mechanism(s) of their protective actions. Our data suggest promising useful insights to garlic and ginger dietary supplementation in broilers that may be safe for consumers from antibiotic toxic metabolites' residues and protective against the risk of infection with bacterial pathogens.
Author Related Publications
Gamal Abdelmoniem Mohamed Abedallah, "Prevalence of plasmid-mediated AmpC in Enterobacteriaceae isolated from humans and from retail meat in Zagazig, Egypt", BMC, 2019
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Gamal Abdelmoniem Mohamed Abedallah, "Nigella sativa seed extract: 1. Enhancement of sheep macrophage inflammatory functions in vitro", Alsevier Ltd, 2013
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Gamal Abdelmoniem Mohamed Abedallah, "Nigella sativa oil extract: A natural novel specific conjugal transfer inhibitor of vancomycin resistance from vanA/B-resistant Enterococcus faecium to Staphylococcus aureus", Wiley, 2022
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Gamal Abdelmoniem Mohamed Abedallah, "1- A trial to develop Monocyte-Derived Macrophages tissue culture system ", لايوجد, 1900
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Gamal Abdelmoniem Mohamed Abedallah, "4- Bovine Viral Diarrhea Virus Down Regulate Monocyte-Derived Macrophages inflammatory Functions ", لايوجد, 1900
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Department Related Publications
Marwa Ibrahim Ibrahiem Abdelhamied, "Impact of Nigella sativa and Clove Oils on Cell Wall Genes Expression in Multidrug Resistant Staphylococcus aureus", Zagazig, Egypt, 2016
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Sarah Youssef Abdelgelil Ahmed, "Use of biological nano zinc as a feed additive in quail nutrition: biosynthesis, antimicrobial activity and its effect on growth, feed utilisation, blood metabolites and intestinal microbiota", taylor and francis, 2021
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Sarah Youssef Abdelgelil Ahmed, "Tomato pomace as a non-traditional feedstuff: Productive and reproductive performance, digestive enzymes, blood metabolites and the deposition of carotenoids into egg yolk in quail breeders", Elsevier Inc, 2022
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