Spectroscopic And Thermal Investigations Of Olanzapine Drug Charge-Transfer Complexes With Various Acceptors

Faculty Specific Education Year: 2019
Type of Publication: ZU Hosted Pages: 98-118
Authors:
Akmal Shawky Gaballa
Journal: Research Journal of Pharmaceutical, Biological and Chemical Sciences Publisher RJPBCS Volume: 10
Keywords : Spectroscopic , Thermal Investigations , Olanzapine Drug Charge-Transfer    
Abstract:
Interactions of Olanzapine drug (OLP) as electron donor with various electron acceptors as iodine (I2), picric acid (HPA), chloranilic acid (H2CA), 2,3-dinitrosalsylic acid (HDNS) and 7,7´,8,8´ Tetracyanoquinodimethane (TCNQ) were studied in the liquid and solid states. The stoichiometries of all complexes were found to be 1:1 molar ratio between olanzapine and acceptors (I2, HPA, H2CA, HDNS and TCNQ). The formed CT-complexes were characterized using UV-Visible spectra, photometric titration measurements, IR and 1H NMR Spectroscopies as well as Thermal analyses. The characteristic physical constants (ID), (f), (KCT), (), (G), (ECT) of the formed CT-complexes are found to be strongly depend on the kind and structure of the electron acceptors
    
     
 
       

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