Synthesis and antimicrobial activity of some nitrogen heterobicyclic systems: Part III

In search for a newer antimicrobial agents, some new nitrogen heterobicyclic systems 3-20 have been synthesized via condensation of the corresponding acetic acid hydrazide 2 with some oxygen compounds. The structures of these target compounds have been elucidated by elemental analysis and spectral data (IR, H-1 NMR and mass). The biocidal activity of the products have also been determined using gentamycin as standard antibiotic. Some compounds show equivalent activity to that of gentamycin towards S. marcesceus.