By 2050, agricultural production has to increase by 7% to face the population increase. This production increase should be attained in a system that preserves the environment and limits the use of pesticides and undesirable chemicals in agriculture. This chapter encapsulates the key sustainability challenges (in terms of conclusions and recommendations) of the existing main agri-food system and presents insights derived from the cases in the volume. In addition, some (update) findings from a few recently published research work are related to the sustainability covered themes. This chapter focuses on the sustainability of the agricultural environment concerning Soil-Water-Plant Nexus in Egypt that was documented in this volume. To this end, we identify four main contribution areas, which include Egyptian sustainable agriculture, the potential application of natural products on crop productivity, biological control potentiality for sustainable agriculture, and livestock contribution to sustaining farm production. Therefore, conclusions will be built on researcher visions gained concerning study findings and limitations. In addition, this chapter contains information on a set of recommendations to direct future research toward sustainability of the agriculture, which is a main strategic theme of the Egyptian government. The set of recommendations is presented for professionals interested in pursuing additional research to exceed the scope and findings of this volume.