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Antimicrobial activity of Silvadoriapersica (Miswak) against multi-drug resistant bacterial clinical isolates
Faculty
Medicine
Year:
2016
Type of Publication:
ZU Hosted
Pages:
Authors:
Ahmed Mohamed Mourad Asaad
Staff Zu Site
Abstract In Staff Site
Journal:
Infectious Diseases (Lond) Hindawi
Volume:
48
Keywords :
Antimicrobial activity , Silvadoriapersica (Miswak) against multi-drug
Abstract:
Much effort has focused on examining the inhibitory effect of Salvadora persica (miswak) on oral microorganisms, but information concerning its antibacterial activity against other human pathogens, particularly multidrug resistant (MDR) isolates, is scarce. Therefore, this study aimed to assess the in vitro antibacterial activities of Salvadora persica L. extracts against 10 MDR bacterial clinical isolates other than oral pathogens. The antibacterial activity of aqueous and methanol miswak extracts was assessed using the agar dilution and minimum inhibitory concentration (MIC) methods. Overall, the 400 mg/mL of miswak extract was the most effective on all strains. The methanol extract exhibited a stronger antibacterial activity against Gram-negative (3.3–13.6 mm) than Gram-positive (1.8–8.3 mm) bacteria. The lowest MIC value was seen for E. coli (0.39, 1.56 µg/mL), followed by Streptococcus pyogenes (1.56 µg/mL). The highest MIC value (6.25, 12.5 µg/mL) was recorded for methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii, and Stenotrophomonas maltophilia. This study demonstrates, for the first time, the moderate to strong antibacterial activity of miswak extracts against all tested MDR-pathogens. Methanol extract appears to be a potent antimicrobial agent that could be considered as complementary and alternative medicine against resistant pathogens. Further studies on a large number of MDR organisms are necessary to investigate and standardize the inhibitory effect of miswak extracts against these emerging pathogens.
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Department Related Publications
Ashwak Mohamed Foad Abotaleb, "تشخيص اصابة عنق الرحم بالكلاميديا تراكوماتيس بواسطه التفاعل المتسلسل لانزيم البلمره", لايوجد, 1900
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Ashwak Mohamed Foad Abotaleb, "اختبار فيروس الالتهاب الكبدي س وتحديد النوع الجينى في المتبرعين بالدم", لايوجد, 1900
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Amal Hassan Mahmoud Atta , "diagnosis of chlamydia trachomatis endo-cervical infection by polymerase chain reaction assay", لايوجد, 1900
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Hanan Mohamed Elsayed Ibrahiem, "Comparison of PCR Assay to Culture for Detection of Vancomycin Resistant Enterococci Colonizing the Intestinal Tract of Hospitalized patients", لايوجد, 1900
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Hanan Mohamed Elsayed Ibrahiem, "Persistance of protective antibody titer following 3-doses regimen hepatitis b vaccination; for how long? 1 /1 /1998 Zagazig University Medical J ", لايوجد, 1900
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