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Inflammatory and oxidative injury is induced in cardiac and pulmonary tissue following fipronil exposure in Japanese quail: mRNA expression of the genes encoding interleukin 6, nuclear factor kappa B, and tumor necrosis factor-alpha
Faculty
Veterinary Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
147-160
Authors:
Mayada Ragab Farag Awadallah
Staff Zu Site
Abstract In Staff Site
Journal:
76 Environmental Pollution
Volume:
Keywords :
Inflammatory , oxidative injury , induced , cardiac and pulmonary
Abstract:
The phenylpyrazole insecticide, fipronil, isused for the eradication of insects in agriculture, which also exposes various non-target groups such as birds and animals. Our aim was to assess the cardiac and pulmonary consequences of sub-acute administration of fipronil (1∕5 LD50; 2.26 mg/kg) in the Japanese quail for fifteen days and to determine the tissue recovery over a period of 60 days. Fipronil exposure led to a significant decrease in the body weight of the treated birds. Its exposure also induced cardiac and pulmonary damage of varying degrees. Fipronil increased the lipid peroxide (LPO) and nitric oxide (NO) contents as well as indices of tissue injury in the serum of exposed birds. Furthermore, it decreased the antioxidant indices in both the organs. Most of these changes gradually reversed and the histological changes, particularly of the heart, reversed completely by day-60 of recovery. Furthermore, alterations in the mRNA gene expressions of Nuclear factor kappa B (NF-kB), Interleukin 6 (IL-6), and Tumor necrosis factor-alpha (TNF-a) were monitored by quantitative polymerase chain reaction (RT-PCR). In both the tissues, a significant up-regulation of the transcripts was recorded after fipronil administration, which was reversed during the recovery period in the heart tissue except for TNF-a, while the transcripts in the lung tissue declined non-significantly. This study showed that the exposure of Japanese quail to fipronil has a profound negative impact on heart and lung including oxidative injury and tissue inflammation. Fipronil can induce the activity of NF-kB inflammatory -signaling pathway that play a role in the associated tissue inflammation. Although most of the cardiac changes could be reversed after a recovery period of sixty days, the pulmonary changes did not reverse much.
Author Related Publications
Mayada Ragab Farag Awadallah, "Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway", Elsevier, 2021
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Mayada Ragab Farag Awadallah, "A comprehensive review on the health benefits and nutritional significance of fucoidan polysaccharide derived from brown seaweeds in human, animals and aquatic organisms", Wiley, 2021
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Mayada Ragab Farag Awadallah, "Palliative Effects of Spirulina platensis Against Cadmium Induced Hepaotoxicity in Albinob Rats", Faculty of Veterinary Medicine, 2015
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Mayada Ragab Farag Awadallah, "Differential susceptibility of kidneys and livers to proliferative processes and transcriptional level of the genes encoding desmin, vimentin, connexin 43, and nestin in rats exposed to furan", elseiver, 2018
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Mayada Ragab Farag Awadallah, "Evaluating the ameliorative efficacy of Spirulina platensis on spermatogenesis and steroidogenesis in cadmium-intoxicated rats", springer, 2016
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Department Related Publications
Walaa Mohamed Alhadi Hassan, "دراسة التأثير السمى الجينى لمبيدى الحشائش الراوند أب والاستومب على سمك القرموط النيلى", مجلة الطب البيطرى - جامعة الزقازيق, 2014
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Amany Abdalaziz , "Appraisal of sub-chronic exposure to lambada-cyhalothrin and/or methomyl on the behavior and hepato-renal functioning in Oreochromis niloticus: Supportive role of taurine-supplemented feed", Elseviere, 2022
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Taghreed Saber Mohamed Sayed Ahmd, "Thymol alleviates imidacloprid-induced testicular toxicity by modulating oxidative stress and expression of steroidogenesis and apoptosis-related genes in adult male rats", Elsevier Inc, 2021
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