This study was conducted to investigate the response of date palm (Phoenix dactylifera, L.) cv Zaghloul, to nine different fertilizer treatments i.e. Control (1.5 N), full nitrogen (N) dose (100%) as mineral fertilizer (recommended rate), quarter organic fertilizers + 3/4 mineral, half-N dose as organic fertilizers + half as mineral, full N dose as organic fertilizer, quarter organic fertilizers + 3/4 mineral + bio-fertilizers (EM). half-N dose as organic fertilizers + half as mineral+ bio-fertilizers, full N dose as organic fertilizer+ bio-fertilizers and bio-fertilizers. The experimental design was complete randomize block design with three replicates under El Adlia, Blbas, Sharkia Governorate, Egypt during two successive years (2017 and 2018). The results showed that full N dose as organic fertilizer+ bio-fertilizers gave the highest leaf number/palm, leaf length and leaf area index. Applied the full N dose as organic fertilizer+ bio-fertilizers gave the highest number of leaflets/leaf and leaflet length whereas; addition bio-fertilizers only produced the highest value of leaflet width. Also, our results clear that added half N dose as organic fertilizers + half as mineral enhanced the leaf chlorophyll content, but the addition full N dose as organic fertilizer+ bio-fertilizers increased carotenoids content. Conclusively, from previous results, it can concluded that organic and bio-fertilizers enhancement all vegetative growth parameters of Zaghloul date palm cv. To reduce dates pollution, prefer replacement mineral fertilizer by organic and bio-fertilizers.