Journal: |
Journal of Gastrointestinal & Digestive System
Journal of Cancer Science & Therapy
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Abstract: |
Background: Bladder cancer is the second most common malignancy among Egyptian males.
Patients and methods: To investigate the factors affecting survival in Egyptian patients suffering from urinary
bladder cancer, we analyzed the geographical patterns of 564 bladder cancers patients from Oncology Departments
of Ain Shams University, Mansoura University, Zagazig University and Damietta oncology centerover a period of 7
years between January 2006 and September 2013.
Results: Among the included 564 patients, Males represented 72.5% of the patients. While, 27.5% were female
with a male to female ratio of 2.6, 227 patients presented with non-metastatic and 337 patients with metastatic
urinary bladder cancer. Grade III was found in 36% of our patients and 60% of them had stage IV. Mean DFS
was (9.15 ± 0.5) and (4.4 ± 0.1) while, mean OS was (13.5 ± 0.7) and (7.5 ± 0.15) months for non-metastatic, and
metastatic patients, respectively. In univariate analysis, patients with no bilharzial infection, Non-SCC, responding
patients had significant better DFS and OS vs. patients with bilharzial infection, SCC, non-responding patients
(respectively, p=0.001 for all). In multivariate analysis, response (OS and PFS), SCC (OS and PFS) and bilharzias
is (OS and PFS) where found to be highly statistically significant (Cox regression, P<0.001 for all) in the metastatic
and non-metastatic group of patients.
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