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Combined bivalent human papillomavirus vaccine and Candida antigen versus Candida antigen alone in the treatment of recalcitrant warts.
Faculty
Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Ayman Mohamed Abdou
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of Cosmetic Dermatology ًWiley
Volume:
Keywords :
Combined bivalent human papillomavirus vaccine , Candida
Abstract:
BACKGROUND: The burden of human papillomavirus (HPV) infection and HPV-associated diseases is consistently growing worldwide. Several combination therapies are being tested nowadays for the treatment of recalcitrant warts, with promising results. AIMS: To evaluate the potential therapeutic role of combined bivalent HPV vaccine (Cervarix) and Candida antigen versus candida antigen alone in the treatment of multiple recalcitrant warts. PATIENTS/METHODS: Forty patients with recalcitrant warts were enrolled into this study. They were divided into two groups (A and B), each including 20 patients. Patients in the group (A) received intralesional Candida antigen injection alone for five sessions at 2-week intervals. Patients in the group B received combined treatment of bivalent recombinant HPV vaccine and intralesional Candida antigen. Candida antigen was administered as in the group A, while Cervarix vaccine was given intramuscularly at 0, 1, and 6 months as scheduled. Follow-up was made monthly for 6 months to detect any possible recurrence. RESULTS: Eight patients (40%) in the group (A) showed complete clearance of warts after intralesional Candida antigen injection alone, while 14 patients (70%) in the group (B) showed complete regression of warts after the combined therapy. No significant side effects were reported in both groups, and no recurrence was detected. CONCLUSION: Bivalent human papillomavirus vaccine combined with Candida antigen is a promising, effective, and safe modality for the treatment of multiple recalcitrant warts.
Author Related Publications
Ayman Mohamed Abdou, "The relationship between expression of Toll-like Receptor 4 in chronic hepatitis C patients and different stages of liver fibrosis", Gastroenterology and Hepatology From Bed to Bench is approved by Iranian Medical Journal Commission, Deputy of Research and Technology, Ministry of He, 2017
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Ayman Mohamed Abdou, "Mycobacterium marinum infection in fish and man: epidemiology, pathophysiology and management; a review", Taylor and Francis, 2018
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Ayman Mohamed Abdou, "Intralesional versus intramuscular bivalent human papillomavirus vaccine in the treatment of recalcitrant common warts", Mosby Inc, 2019
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Ayman Mohamed Abdou, "Bacillus Calmette-Guerin, polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus.", Blackwell Publishing Inc, 2018
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Ayman Mohamed Abdou, "Role of mannose binding lectin in response to candida antigen immunotherapy of warts", talyor &francis, 2019
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Department Related Publications
Ashwak Mohamed Foad Abotaleb, "مدى انتشار فيروس الالتهاب الكبدى سي فيروس الالتهاب الكبدي ب فيروس فقد المناعه المكتسبة بين متبرعي الدم بالشرقية", لايوجد, 1900
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