Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Dentate gyrus neurogenesis across different ages in male rats: an immunohistochemical approach
Faculty
Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Mai Amin Mohamed Mahmoud Samak
Staff Zu Site
Abstract In Staff Site
Journal:
Environmental Science and Pollution Research springer
Volume:
Keywords :
Dentate gyrus neurogenesis across different ages
Abstract:
Dentate gyrus is a fundamental sub-region of the hippocampus which is directly engaged in higher memory and cognitive functions. This study was performed to describe the histological and immunohistochemical changes in dentate gyrus in experimental animals during postnatal development. Forty four male albino rats were classified into four equal groups: new born group aged one day, adult group aged 3–6 months, early senile group aged 18–20 months and late senile group aged 30–31 months. Specimens of hippocampus were processed and prepared for routine hematoxylin and eosin stains and immunohistochemical expressions of calretinin, glial fibrillary acidic protein and Ki67 (Kiel 67). Morphometric data were statistically analyzed. The present results showed significant reduction in thickness of granule cell layer of late senile group. Interestingly, the mean number of immature neurons was significantly increased in early senile group, while it was significantly reduced in late senile group. The number of mature granule cells showed marked reduction in both early and late senile groups. Furthermore, the number of astrocytes and optical density of glial fibrillary acidic protein revealed significant age-dependent increase. Measurable difference in number of calretinin positive interneurons was detected between adult and senile groups. However, mean number of Ki67 immune positive nuclei expressed significant age-dependent reduction. This study concluded that interneurons play a substantial role in modulating dentate gyrus neurogenesis which occurs throughout life and steadily decreases during aging. It is recommended to focus on the different stimuli and factors that potentiate neurogenesis to prevent or treat cognitive deficiencies associated with aging.
Author Related Publications
Mai Amin Mohamed Mahmoud Samak, "Could curcumin ameliorate titanium dioxide nanoparticles effect on the heart? A histopathological, immunohistochemical, and genotoxic study", Springer Berlin Heidelberg, 2019
More
Mai Amin Mohamed Mahmoud Samak, "Therapeutic potentials of mesenchymal stem cells on the renal cortexof experimentally induced hypertensive albino rats: Relevant role ofNrf2", Tissue and Cell, 2017
More
Mai Amin Mohamed Mahmoud Samak, "Fluoxetine pretreatment enhances neurogenic, angiogenic and immunomodulatory effects of MSCs on experimentally induced diabetic neuropathy", Cell and Tissue Research, 2018
More
Mai Amin Mohamed Mahmoud Samak, "Synergistic therapeutic effects of Vitis vinifera extract and Silymarin on experimentally induced cardiorenal injury: The pertinent role of Nrf2", elsevier., 2019
More
Mai Amin Mohamed Mahmoud Samak, "Therapeutic Prospects of Hydroxytyrosol on Experimentally Induced Diabetic Testicular Damage: Potential Interplay with AMPK Expression.", springer, 2019
More
Department Related Publications
Osama Yassen Ibrahim Mohamed, "مناطق النقص الدقيق AZFa, AZFb AND AZFc لكروموسوم الجنس Y فى حالة ندرة الحيوانات المنوية ظاهريا ", لايوجد, 1900
More
Osama Yassen Ibrahim Mohamed, "دراسة هستولوجية عن تأثير مرض البول السكري المستحدث تجريبيا على المثانة البولية في ذكور الجرذان البيضاء البالغة", لايوجد, 1900
More
Osama Yassen Ibrahim Mohamed, "التغيرات النسيجية و العضيية الدقيقة فى كبد الفأر الأبيض بعد اجراء عملية استئصال جزئى للكبد", لايوجد, 1900
More
Gamal Abdallah Attya, "The effect of repeated injections of ketamine (Ketalar) on the liver and kidney of albino rats (Histological and histochemical study)", لايوجد, 1900
More
Gamal Abdallah Attya, "Histological and histochemical study of human foreskinin comparison to abdominal skin", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف