Nausea and vomiting are the most common side effects associated with the usage of chemotherapy among breast cancer women . Aim of this study was to investigate the effectiveness of progressive muscle relaxation technique on chemotherapy-induced nausea and vomiting among breast cancer women. Subjects and Methods: Research design: Quasi-experimental design was used to achieve the aim of the current study. Setting: The current study was conducted in outpatient oncology clinics at Zagazig University Hospitals..Subjects: Study sample was 56 women and divided into two groups (progressive muscle relaxation and control). They are on routine care and regular treatment Tools: Interview questionnaire consists of five parts were used for data collection: Demographic characteristics and medical history. risk factors for nausea and vomiting, awareness regarding complementary therapy, the Index of Nausea, Vomiting and Retching (INVR))and behavioral relaxation self rating scale. Results: The results showed that the mean scores of total occurrence, experience, distress for nausea ,vomiting ,retching in progressive muscle relaxation group were statistically significant decreased compared to control group through out follow up days, Additionally, number of antiemetic decreases in intervention group compared to control group (p<0.05). Additionally number of antiemetic drugs decreased in acupressure group compared to control group. Conclusion: progressive muscle relaxation technique is positively affect nausea, vomiting and retching among breast cancer patients. Recommendation: progressive muscle relaxation as non pharmacological techniques should be carried out as supportive nursing intervention strategies to relieve chemotherapy induced nausea and vomiting in breast cancer patients