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Anti-arthritic effect of β-caryophyllene and its ameliorative role on methotrexate and/or leflunomide-induced side effects in arthritic rats
Faculty
Veterinary Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Azza Ahmed Abdelghafar Gala
Staff Zu Site
Abstract In Staff Site
Journal:
Life Sciences Elseiver
Volume:
Keywords :
Anti-arthritic effect , β-caryophyllene , , ameliorative role , methotrexate
Abstract:
Aim Rheumatoid arthritis (RA) is the most widespread inflammatory arthropathy, which causes severe disability. It is highly important to ameliorate the side effects caused by different drugs used to treat RA. Therefore, this study assessed the potential role of β-caryophyllene (BCP) in treating adjuvant-induced arthritis (AIA), increasing the efficacy of methotrexate (MTX) and/or leflunomide (LEF), and ameliorating their side effects. Material and methods AIA was induced in rats by injecting complete Freund’s adjuvant. The rats were divided into different groups such as sham group; control group; monotherapy groups, including BCP (300 mg/kg), MTX (1 mg/kg), and LEF (10 mg/kg); and combined groups, including MTX+BCP, LEF+BCP, MTX+LEF, and MTX+LEF+BCP groups. Key findings Monotherapy with BCP or MTX or LEF as well as MTX+LEF significantly reduced paw thickness and arthritic index; the histopathological changes in hind paw joints were recovered; and oxidative stress and tumor necrosis factor-alpha (TNF-𝛼) levels in arthritic rats were reduced. The co-administration of BCP and MTX and/or LEF significantly improved the therapeutic efficacy of MTX and/or LEF and significantly reduced the myelosuppressive and hepatotoxic effects of MTX and/or LEF. Taken together, BCP could be used with MTX and/or LEF for the treatment of RA to reduce the side effects of the drugs and increase their efficacy.
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Azza Ahmed Abdelghafar Gala, "Protective effect of Zingiber officinale (ginger) on doxorubicin induced oxidative cardiotoxicity in rats.", Life Science Journal, 2013
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Azza Ahmed Abdelghafar Gala, "Toxic effects of sub-chronic exposure of male albino rats to emamectin benzoate and possible ameliorative role of Foeniculum vulgare essential oil", Elsevier, 2015
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