Domperidone (Dom) possesses a potent antiemetic property, it increases the movements or contractions of the stomach and bowel. The current research aimed to synthesize and study the charge transfer (CT) complexes that originated from the interaction between Dom and different types of organic π-acceptors (PA, DNP, TCNQ, DDQ, DBQ, and DCQ). The targeted CT products were synthesized in methanol media, isolated, and thoroughly characterized by elemental analyses and spectroscopies (UV–Visible, IR, Raman, and 1H NMR). The thermal decomposition data of these products (from simultaneous TG analysis) were presented and discussed as well. Furthermore, the products' structural morphology was visualized by XRD and SEM-EDX. The results showed that the products have organized and homogeneously dispersed, uniform microstructures in the nanometer range.