Background: Excimer laser therapy of vitiligo generally takes months to years to achieve excellent outcomes. Platelet‐rich plasma is an autologous preparation with a focus on various growth factors that can help with vitiligo repigmentation. Objectives: To assess the additive effect of PRP in the therapy of vitiligo on the results of the excimer laser. Patients and Methods: A comparative study included 52 patients (8 males and 44 females) in two groups with stable (no new lesion for 6 months), nonsegmental and symmetrical vitiligo. Group I (26 patients): The patient was treated by intradermal PRP injection and the excimer laser, while group II (26 patients) was treated with the excimer laser only. The PRP injection was repeated every 3 weeks for 4 months and excimer laser two times a week and for 16 weeks till complete response. VAS for patient's satisfaction assessment, safety assessment for complications, and follow‐up for 3 months was done. Clinical (repigmentation response) and histopathological assessment was done. Results: There was a higher statistically significant treatment response in group I compared with group II. In addition, a statistically significant correlation between the treatment response and the lesion site in group I (P < .000). A significant difference in VAS between both groups (P < .000). Few the side effects were reported. Conclusion: The combination of PRP and excimer laser phototherapy is an efficient vitiligo treatment as PRP increases the excimer laser impact and also improves the result.