Infertility affects 15% of couples worldwide. It is estimated that roughly half of the infertility cases are due tomale factors .Male infertility could be caused by various reasons including failure in spermatogenesis, defects in sperm transportation or accessory gland function, genetic or environmental factors, and sexual disorders . Among these causes, spermatogenic defect is the primary one in male infertility. Spermatogenesis is a sophisticated multistep process involving three major phases: mitotic, meiotic, and postmeiotic phases. Other cellular events such as apoptosis of r spermatogenic cell, migration, and differentiation also play vital roles in the process of spermatogenesis. The dynamic balance between cell proliferation and apoptosis determines the number of cells in the seminiferous tubules of the testis.Aim:Compare between the effect of honey bee , bovine colostrum and G-CSF on homing of HSCs that are used fo2 treatment of induced infertility in experimental animals.Materials&Methods: Seventy male mice were randomly divided 23 into seven groups ,six of theminjected with cyclophosphamide to be infertile , then first group treated with honey,second treated with bovine colostrum ,third treated with MSCs,fourth treated with G-CSF , fifth treated with wheat germ, sixth saved as positive control groupand seventh left as negative control group.The 2nd generation of stem cells were injected intraperitoneally. Different tissue and blood samples were taken at the end of study for tests. Results: Male fertility is improved by increasing sperm count and motility and level of sex hormones is elevated after the period of study.