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Treatment of diarrhea caused by Giardia intestinalis and Entamoeba histolytica or E-dispar: A randomized, double-blind, placebo-controlled study of nitazoxanide
Faculty
Medicine
Year:
2001
Type of Publication:
Article
Pages:
381-384
Authors:
Rossignol, JF, Ayoub, A, Ayers, MS
DOI:
10.1086/322038
Journal:
JOURNAL OF INFECTIOUS DISEASES UNIV CHICAGO PRESS
Volume:
184
Research Area:
Immunology; Infectious Diseases; Microbiology
ISSN
ISI:000169961600021
Keywords :
Treatment , diarrhea caused , Giardia intestinalis , Entamoeba
Abstract:
A prospective randomized, double-blind, placebo-controlled study was conducted to assess the efficacy and safety of nitazoxanide in the treatment of diarrhea caused by Giardia intestinalis or Entamoeba histolytica and/or E. dispar in 89 adults and adolescents, 22 of whom were diagnosed with G. intestinalis, 53 with E. histolytica and/or E. dispar, and 14 with both G. intestinalis and E. histolytica and/or E. dispar. The study medication was administered as 1 nitazoxanide 500-mg tablet or a matching placebo twice daily for 3 days. Thirty-eight (81\%) of 47 patients in the nitazoxanide treatment group resolved diarrhea within 7 days (median, 3 days) after initiation of treatment, versus 17 (40\%) of 42 in the placebo group (P = .0002). With its efficacy in treating a broad spectrum of enteric protozoan pathogens, nitazoxanide could play an important role in the management of diarrhea caused by enteric protozoa, reducing morbidity and costs associated with these diarrheal illnesses.
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