Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
LC and TLC determination of cinnarizine in pharmaceutical preparations and serum
Faculty
Science
Year:
2002
Type of Publication:
Article
Pages:
711-719
Authors:
HASSAN, SSM, Elmosallamy, MAF, Abbas, AB
DOI:
10.1016/S0731-7085(01)00662-8
Journal:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS PERGAMON-ELSEVIER SCIENCE LTD
Volume:
28
Research Area:
Chemistry; Pharmacology \& Pharmacy
ISSN
ISI:000176160000033
Keywords :
high performance liquid chromatography, thin layer densitometry, cinnarizine assay, cinnarizine photo- and acid-degradation products, tablet dissolution rate, bioequivalency, bioavailability
Abstract:
New high performance liquid chromatography (HPLC) and thin layer densitometry (TLC) methods are developed for quantification of cinnarizine in dosage forms in the presence of its photo-degradation products and related substances and in the presence of its metabolites in serum. Mobile phases consisting of benzene-methanol-formic acid (80:17:3) and methanol-acetate buffer of pH 4 (70:30) are satisfactorily used for resolution of cinnarizine from associated substances by TLC and HPLC techniques, respectively. The lower detection limits are 16 and 10 ng mul (-1) of cinnarizine with standard deviations of 1.3 and 1.1\% with TLC and HPLC, respectively. The methods are used for assessment of drug purity, stability, bioavailability, bioequivalency and tablet dissolution rate. Four cinnarizine related substances and six drug degradation products are isolated and identified by infrared and mass spectrometry. The results obtained by both techniques are in good agreement and offer the advantages of reproducibility and accuracy. (C) 2002 Elsevier Science B.V. All rights reserved.
Online
PDF
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف