: Synthesis and anti-HCV activity of β-D-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-D-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides and their phosphoramidate prodrugs.

Faculty Science Year: 2019
Type of Publication: ZU Hosted Pages: 75-80
Authors:
Ahmed Khalil Elsayed Khalil
Journal: American Journal of Nursing Science Elsevier Volume: 2
Keywords : , Synthesis , anti-HCV activity , β-D-2′-deoxy-2′-α-chloro-2′-β-fluoro , β-D-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides    
Abstract:
We report herein the synthesis and evaluation of a series of β-D-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-D-2′- deoxy-2′-α-bromo-2′-β-fluoro nucleosides along with their corresponding phosphoramidate prodrugs. Key intermediates, lactols 11 an
    
     
 
       

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