Synthesis and anti-HCV activity of β-D-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-D-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides and their phosphoramidate prodrugs.

Faculty Science Year: 2019
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Khalil Elsayed Khalil
Journal: Bioorganic & Medicinal Chemistry Elsevier Volume:
Keywords : Synthesis , anti-HCV activity , β-D-2′-deoxy-2′-α-chloro-2′-β-fluoro , β-D-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides    
Abstract:
We report herein the synthesis and evaluation of a series of β-D-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-D-2′- deoxy-2′-α-bromo-2′-β-fluoro nucleosides along with their corresponding phosphoramidate prodrugs. Key intermediates, lactols 11 an
    
     
 
       

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  • Ahmed Khalil Elsayed Khalil, "2'-Chloro,2'-fluoro ribonucleotide prodrugs with potent pan-genotypic activity against Hepatitis C Virus replication in culture", ACS, 2017 More

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  • Abd El Shafey Ibrahim Ahmed Ibrahim, "Optimizing halogenation conditions of N-halamine polymers and investigating mode of bactericidal action", Copyright © 2009 Wiley Periodicals, Inc., 2009 More
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