Synthesis and anti-HCV activity of β-D-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-D-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides and their phosphoramidate prodrugs.

Faculty Science Year: 2019
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Khalil Elsayed Khalil
Journal: Bioorganic & Medicinal Chemistry Elsevier Volume:
Keywords : Synthesis , anti-HCV activity , β-D-2′-deoxy-2′-α-chloro-2′-β-fluoro , β-D-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides    
Abstract:
We report herein the synthesis and evaluation of a series of β-D-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-D-2′- deoxy-2′-α-bromo-2′-β-fluoro nucleosides along with their corresponding phosphoramidate prodrugs. Key intermediates, lactols 11 an
    
     
 
       

Author Related Publications

  • Ahmed Khalil Elsayed Khalil, "Synthesis, biological evaluation, and radioiodination of halogenated closo-carboranylthymidine analogues", ACS, 2011 More
  • Ahmed Khalil Elsayed Khalil, "Iodine monochloride facilitated deglycosylation, anomerization, and isomerization of 3-substituted thymidine analogues.", Taylor & Francis, 2014 More
  • Ahmed Khalil Elsayed Khalil, "Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogs for boron neutron capture therapy of cancer.", Elsevier, 2015 More
  • Ahmed Khalil Elsayed Khalil, ": Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans.", Elsevier, 2014 More
  • Ahmed Khalil Elsayed Khalil, "2'-Chloro,2'-fluoro ribonucleotide prodrugs with potent pan-genotypic activity against Hepatitis C Virus replication in culture", ACS, 2017 More

Department Related Publications

  • Abd El Shafey Ibrahim Ahmed Ibrahim, "Optimizing halogenation conditions of N-halamine polymers and investigating mode of bactericidal action", Copyright © 2009 Wiley Periodicals, Inc., 2009 More
  • Maher Abdul Rahman Shams al-Din Safty, "Kinetic studies for pyrolysis of wheat straw", لايوجد, 1900 More
  • Maher Abdul Rahman Shams al-Din Safty, "some reactions with 1,4 diphenyl - 1:2 , 3:4 - diepoxybutane", لايوجد, 1900 More
  • Maher Abdul Rahman Shams al-Din Safty, "structural group analysis of asphaltic fractions of U.A.R. crude oils ", لايوجد, 1900 More
  • Maher Abdul Rahman Shams al-Din Safty, "preparation and some reactions of 1:4 diaryl - 1,3 dicarboxaldehyde", لايوجد, 1900 More
Tweet