2'-Chloro,2'-fluoro ribonucleotide prodrugs with potent pan-genotypic activity against Hepatitis C Virus replication in culture

Faculty Science Year: 2017
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Khalil Elsayed Khalil
Journal: Bioorganic & Medicinal Chemistry ACS Volume:
Keywords : 2'-Chloro,2'-fluoro ribonucleotide prodrugs with potent pan-genotypic    
Abstract:
Pan-genotypic nucleoside HCV inhibitors display a high genetic barrier to drug resistance and are the preferred direct-acting agents to achieve complete sustained virologic response in humans. Herein, we report, the discovery of a β-D-2′-Cl
    
     
 
       

Author Related Publications

  • Ahmed Khalil Elsayed Khalil, "Synthesis, biological evaluation, and radioiodination of halogenated closo-carboranylthymidine analogues", ACS, 2011 More
  • Ahmed Khalil Elsayed Khalil, "Iodine monochloride facilitated deglycosylation, anomerization, and isomerization of 3-substituted thymidine analogues.", Taylor & Francis, 2014 More
  • Ahmed Khalil Elsayed Khalil, "Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogs for boron neutron capture therapy of cancer.", Elsevier, 2015 More
  • Ahmed Khalil Elsayed Khalil, ": Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans.", Elsevier, 2014 More
  • Ahmed Khalil Elsayed Khalil, "Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans.", Elsevier, 2018 More

Department Related Publications

  • Maher Abdul Rahman Shams al-Din Safty, "synthesis and behaviour of 4-(4-chloro-3-methyl) phenyl- (2H)-phthalazinone towards some elecrophiles and nucleophiles", لايوجد, 1900 More
  • Wael Salah AbdelHalim, "Artificial polarization effects on F_A1^∶Sr^(2+), lasers and NO interactions at NaCl (001) surface: First principles calculations", elsevier, 2007 More
  • Wael Salah AbdelHalim, "Ab initio defect based model for laser light generation and color image formation at the flat, edge and corner surfaces of AgBr: F_A1^∶Cs^+ and F_A2^∶Li^+", elsevier, 2005 More
  • Hamdy Aldedamony , "Effect of delayed addition time of synthesized SSPF condensate on the durability of sulphate resisting cement pastes incorporating micro-silica", Constructing and building materials, 2014 More
  • Hamdy Aldedamony , "Behavior of delayed addition time of SNF superplasticizer on microsilica-sulphate resisting cements.", Ceramics – Silikáty, 2014 More
Tweet