2'-Chloro,2'-fluoro ribonucleotide prodrugs with potent pan-genotypic activity against Hepatitis C Virus replication in culture

Faculty Science Year: 2017
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Khalil Elsayed Khalil
Journal: Bioorganic & Medicinal Chemistry ACS Volume:
Keywords : 2'-Chloro,2'-fluoro ribonucleotide prodrugs with potent pan-genotypic    
Abstract:
Pan-genotypic nucleoside HCV inhibitors display a high genetic barrier to drug resistance and are the preferred direct-acting agents to achieve complete sustained virologic response in humans. Herein, we report, the discovery of a β-D-2′-Cl
    
     
 
       

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  • Abd El Shafey Ibrahim Ahmed Ibrahim, "Optimizing halogenation conditions of N-halamine polymers and investigating mode of bactericidal action", Copyright © 2009 Wiley Periodicals, Inc., 2009 More
  • Abd El Shafey Ibrahim Ahmed Ibrahim, "Metabolomic profiling can differentiate between bactericidal effects of free and polymer bound halogen", لايوجد, 2010 More
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  • Abd El Shafey Ibrahim Ahmed Ibrahim, "Halamine polymers: 1. Preparation and characterization of new pyrimidinone biocidal polymers based on poly-4-vinylacetophenone", emerald, 2004 More
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