2'-Chloro,2'-fluoro ribonucleotide prodrugs with potent pan-genotypic activity against Hepatitis C Virus replication in culture

Faculty	Science	Year:	2017
Type of Publication:	ZU Hosted	Pages:
Authors:	Ahmed Khalil Elsayed Khalil Staff Zu Site Abstract In Staff Site
Journal:	Bioorganic & Medicinal Chemistry ACS	Volume:

Keywords :	2'-Chloro,2'-fluoro ribonucleotide prodrugs with potent pan-genotypic
Abstract:	Pan-genotypic nucleoside HCV inhibitors display a high genetic barrier to drug resistance and are the preferred direct-acting agents to achieve complete sustained virologic response in humans. Herein, we report, the discovery of a β-D-2′-Cl

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