Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogs for boron neutron capture therapy of cancer.

Faculty Science Year: 2015
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Khalil Elsayed Khalil
Journal: Bioorganic & Medicinal Chemistry Elsevier Volume:
Keywords : Synthesis , evaluation , thymidine kinase 1-targeting carboranyl    
Abstract:
A library of sixteen 2nd generation amino- and amido-substituted carboranyl pyrimidine nucleoside analogs, designed as substrates and inhibitors of thymidine kinase 1 (TK1) for potential use in boron neutron capture therapy (BNCT) of cancer
    
     
 
       

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  • Ahmed Khalil Elsayed Khalil, "Synthesis, biological evaluation, and radioiodination of halogenated closo-carboranylthymidine analogues", ACS, 2011 More
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  • Ahmed Khalil Elsayed Khalil, ": Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans.", Elsevier, 2014 More
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  • Ahmed Khalil Elsayed Khalil, "Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans.", Elsevier, 2018 More

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