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Bioactive kaurane diterpenes and coumarins from Fortunella margarita
Faculty
Pharmacy
Year:
2003
Type of Publication:
Article
Pages:
143-147
Authors:
El-Shafae, AM, Ibrahim, MA
Journal:
PHARMAZIE GOVI-VERLAG GMBH
Volume:
58
Research Area:
Pharmacology \& Pharmacy; Chemistry
ISSN
ISI:000181123400014
Keywords :
Bioactive kaurane diterpenes , coumarins from Fortunella
Abstract:
Two bioactive pyranocoumarins 1 (sesselin) and 3 (xanthyletin) and one prenylated coumarin 2 (suberosin), beside three rare kaurene diterpenes 5-7 were isolated from the roots of Fortunella margarita. Their structures were determined from their spectroscopic data, including H-1/C-13 2D NMR experiments. The kaurene diterpenes 5-7 are reported in Rutaceae for the first time. Diterpene 5 was found to be a potent stimulator of uterine contraction; it also caused stimulation of brain activity.
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