Pyrrolizidine alkaloids from Onosma arenaria (Boraginaceae)

Faculty Pharmacy Year: 2003
Type of Publication: Article Pages: 477-485
Authors:
Wink, M, El-Shazly, A, Abdel-Ghani, A
DOI: 10.1016/S0305-1978(02)00177-1
Journal: BIOCHEMICAL SYSTEMATICS AND ECOLOGY PERGAMON-ELSEVIER SCIENCE LTD Volume: 31
Research Area: Biochemistry \& Molecular Biology; Environmental Sciences \& Ecology; Evolutionary Biology ISSN ISI:000181995900003
Keywords : Onosma arenaria, Boraginaceae, pyrrolizidine alkaloids, uplandicine, NMR, gas liquid chromatography (GLC), GLC-mass spectrometry    
Abstract:
Uplandicine, a 1,2-unsaturated pyrrolizidine alkaloid esterified with acetyl and echimidinyl moieties at C-7 and C-9, respectively, was isolated as a major component from the alkaloid extract of Onosma arenaria. Its structure was confirmed by MS (EI and positive FAB), 1H- and 13C-NMR analysis. Furthermore, nine minor alkaloids were identified on the basis of mass spectral data and/or Kovats retention indices. (C) 2003 Published by Elsevier Science Ltd.
    
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