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Novel ibuprofen potentiometric membrane sensors based on tetraphenylporphyrinato indium(III)
Faculty
Science
Year:
2003
Type of Publication:
Article
Pages:
675-679
Authors:
HASSAN, SSM, Elmosallamy, MAF, Mahmoud, WH, Almarzooqi, MH
DOI:
10.2116/analsci.19.675
Journal:
ANALYTICAL SCIENCES JAPAN SOC ANALYTICAL CHEMISTRY
Volume:
19
Research Area:
Chemistry
ISSN
ISI:000182900300006
Keywords :
Novel ibuprofen potentiometric membrane sensors based
Abstract:
Two novel potentiometric membrane sensors responsive to the ibuprofen drug have been developed. These incorporate poly(vinyl chloride) and polyurethane matrix membranes containing 5,10,15,20-tetraphenylporphrinato (TPP) indium(III) ionophore plasticized with dibutylsebacate. The sensors show a near-Nernstian response with anionic slopes of -53 and -55 mV decade(-1), over the concentration range of 4.2 x 10(-6) - 1.0 x 10(-2) and 3.3 x 10(-6) - 1.0 x 10(-2) M ibuprofen within pH ranges of 4 - 9 and 5 - 9 for PVC and PU matrix membranes, respectively. A sensor based on a polyurethane membrane displays a lower detection limit and a wider linear working range, and a sensor based on a PVC membrane exhibits a better overall selectivity, especially in the presence of lipophilic organic anions. Both sensors are used for the quantification and quality-control assessment of ibuprofen in pharmaceutical preparations. The average recoveries are 99.1+/-0.3\% and 99.3+/-0.3\% for TPP In(Ill)-PVC and TPP In(Ill)-PU based membrane sensors, respectively. High selectivities towards ibuprofen in the presence of many anions, drug excipients and diluents are offered by both sensors, which exhibit a non-Hofmeister selectivity pattern.
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