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Biological responses of xenobiotic metabolizing enzymes to lead exposure in cultured H4IIE rat cells
Faculty
Veterinary Medicine
Year:
2013
Type of Publication:
Article
Pages:
S48-S53
Authors:
Darwish, Wageh Sobhy, Ikenaka, Yoshinori, Ishizuka, Mayumi
Journal:
JAPANESE JOURNAL OF VETERINARY RESEARCH HOKKAIDO UNIV
Volume:
61
Research Area:
Veterinary Sciences
ISSN
ISI:000324450300007
Keywords :
lead, xenobiotic metabolizing enzymes, rat
Abstract:
This study was undertaken to investigate the constitutive response of xenobiotic metabolizing enzymes (XMEs) to lead (Pb2+) exposure in cultured rat liver (H4IIE) cell lines. Phase I enzymes such as CYP1A1 and CYP1A2 had mRNA expressions that were slightly induced after exposure to low concentrations of Pb2+; however, under higher concentrations of Pb2+, the mRNA expressions of CYP1A1 and CYP1A2 were significantly down-regulated. These effects were in correspondence with AhR mRNA expression. Phase II enzymes had mRNA expressions that were reduced upon exposure to Pb2+. Metallothionein mRNA expression was induced after treatment with Pb2+ in a dose-dependent trend. In conclusion, Phase I and II enzymes were significantly modulated upon lead exposure indicating some toxicological implications for lead exposure in cultured H4IIE cells.
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