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Pyridazine derivatives and related compounds, Part 9. Tetrazolo{[}1,5-b]pyridazine-8-carbohydrazide synthesis and some reactions
Faculty
Science
Year:
2003
Type of Publication:
Article
Pages:
1873-1879
Authors:
DEEB, A, Saad, H
Journal:
HETEROCYCLES PERGAMON-ELSEVIER SCIENCE LTD
Volume:
60
Research Area:
Chemistry
ISSN
ISI:000184978500011
Keywords :
Pyridazine derivatives , related compounds, Part , Tetrazolo{[}1,5-b]pyridazine-8-carbohydrazide
Abstract:
The reaction of the hydrazide of 6,7-diphenyltetrazolo{[}1,5-b]pyridazine-8-carboxylic acid (3) with aromatic aldehydes gave 8-arylidenecarbohydrazide derivatives. The reaction of 3 with methanesulfonyl chloride, benzenesulfonyl chloride, phenyl and benzyl isothiocyanates afforded the corresponding N-substituted derivatives. The reaction of 3 with potassium ethylxanthate gave 5 (6,7-diphenyltetrazolo{[}1,5-b]pyridazin-8-yl)-1,3,4-oxadiazole-2-thione (7). The alkylation of this product in an alkaline medium proceeds at the sulfur atom, while the aminomethylation and acylation proceed at the nitrogen atom. Compound (3) also reacted with N-aminothiosemicarbazide to give 4-amino-5-(6,7-diphenyltetrazolo{[}1,5-b]pyridazin-8-yl)-1,2,4-triazole- 3-thione (11).
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