A facile one-pot synthesis of fused 2-thiouracils: Dipyrimidinopyridine, pyrazolopyrimidine and pyridazinopyrimidines

Faculty	Science	Year:	2003
Type of Publication:	Article	Pages:	1429-1432
Authors:	YOUSSIF, S, El-Bahaie, S, Nabih, E
Journal:	BULLETIN OF THE KOREAN CHEMICAL SOCIETY KOREAN CHEMICAL SOC	Volume:	24
Research Area:	Chemistry	ISSN	ISI:000186413100003
Keywords :	dipyrimidinopyridine, pyrazolo[5, 4-d]pyrimidines, pyrazolylpyrimidine, indolodiazinopyrimidine and pyridazino[6, 5-d]pyrimidine
Abstract:	A novel fused thiouracil containing a heterocyclic ring system, dipyrimidinopyridine (3), has been prepared through the cyclization of compound 2. Compound 2 was formed by the formylation of 6-amino-2-thiouracil 1, pyrazolopyrimidines 8-10 via the heating of 6-arylhydrazono-2-thiouracils 5-7, compound 11, using Vilsmeier reagent with compound 4, pyrazolylpyrimidine 12, indolodiazinopyrimidine 14 and pyridazino-pyrimidine 15. Pyridazino-pyrimidine 15 was formed by the condensation of compound 4 with acetylacetone, isatin and benzyl, respectively.
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