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Association of microRNAs genes polymorphisms with rheumatoid arthritis in Egyptian female patients
Faculty
Medicine
Year:
2013
Type of Publication:
Article
Pages:
626-631
Authors:
El-Shal, Amal S, Aly, Nader M, Galil, Sahar M. Abdel, Moustafa, Mohamed A, Kandel, Wael A
DOI:
10.1016/j.jbspin.2013.03.005
Journal:
JOINT BONE SPINE ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Volume:
80
Research Area:
Rheumatology
ISSN
ISI:000327770300013
Keywords :
Rheumatoid arthritis, MicroRNA, Polymorphism, Egyptian population
Abstract:
Objective: To investigate whether miRNA-499 (rs3746444) and miRNA-146a (rs2910164) genes polymorphisms are independent factors for rheumatoid arthritis (RA) in Egyptians, and whether they influence disease severity and activity. Methods: Two hundred and seventeen RA patients and 245 healthy controls were enrolled in this study. Polymorphisms of miRNA-146a and miRNA-499 genes were detected using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results: The miRNA-499 CT genotype was an independent factor of RA. The miRNA-499 CT, CC genotypes and C allele frequencies were significantly increased in erosive RA group. Moreover, the heterozygote CT had more severe and more active form of the disease compared with homozygote CC or TT. However, we did not find any significant association of miRNA-146a polymorphism with RA risk, severity, and activity. Conclusion: The miRNA-499 polymorphism is an independent factor of RA, and influences disease severity and activity. (C) 2013 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
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