“Methylene Bridge” to 5-HT3 Receptor Antagonists Conformationally Constrained Phenylguanidines

Faculty Pharmacy Year: 2018
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Samy Abdelsamad Abdelkhalek hilal
Journal: ACS Chemical Neuroscience American Chemical Society Volume:
Keywords : “Methylene Bridge” , 5-HT3 Receptor Antagonists Conformationally    
Abstract:
Arylguanidines, depending upon their aromatic substitution pattern, display varying actions at 5-HT3 receptors (e.g., partial agonist, agonist, superagonist). Here, we demonstrate that conformational constraint of these agents as dihydroqui
    
     
 
       

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