Cyano Modification on Uridine Decreases Base-Pairing
Stability and Specificity through Neighboring Disruption
in RNA Duplex

Faculty	Science	Year:	2018
Type of Publication:	ZU Hosted	Pages:
Authors:	Abdullah Elsayed Abdullah Hassan Staff Zu Site Abstract In Staff Site
Journal:	ChemBioChem Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim	Volume:

Keywords :	Cyano Modification , Uridine Decreases Base-Pairing Stability , Specificity
Abstract:	5-Cyanomethyluridine (cnm5U) and 5-cyanouridine (cn5U), the two uridine analogues, were synthesized and incorporated into RNA oligonucleotides. Base-pairing stability and specificity studies in RNA duplexes indicated that cnm5U slightly

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