Design and Synthesis of Hydrazide-Hydrazones Based 2-Oxonicotinonitrile Derivatives as Potential Antimicrobial Agents

Faculty Science Year: 2018
Type of Publication: ZU Hosted Pages: 791-808
Authors:
Ahmed Heussein Mostafa
Journal: Medicinal Chemistry natural science Volume: 14
Keywords : Design , Synthesis , Hydrazide-Hydrazones Based 2-Oxonicotinonitrile Derivatives    
Abstract:
Synthesis and antimicrobial screening of new series of hydrazide-hydrazones were described. Where, regiospacific alkylation of 2-oxonicotinonitriles1a,b with ethyl bromoacetate followed by hydrozinolys is afforded acetic acid hydrazides3a,b
    
     
 
       

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