Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase.

Faculty Pharmacy Year: 2018
Type of Publication: ZU Hosted Pages:
Authors:
Kamel Abdelrehem Metwaly Bayomy
Journal: European Journal of Medicinal Chemistry Elsevier Volume:
Keywords : Design, synthesis, structure-activity relationships , X-ray structural    
Abstract:
Human aldose reductase (AKR1B1, AR) is a key enzyme of the polyol pathway, catalyzing the reduction of glucose to sorbitol at high glucose concentrations, as those found in diabetic condition. Indeed, AKR1B1 overexpression is related to dia
    
     
 
       

Author Related Publications

  • Kamel Abdelrehem Metwaly Bayomy, "Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study", ELSEVIER, 2017 More
  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and anticancer activity of novel quinazolinone‑based rhodanines", Springer Open, 2017 More
  • Kamel Abdelrehem Metwaly Bayomy, "Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", taylor and francis online, 2016 More
  • Kamel Abdelrehem Metwaly Bayomy, "Targeting methionyl t RNA synthetase: design ,synthesis and antibacterial activity against clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", Journal of Enzyme Inhibition and Medicinal Chemistry, 2016 More
  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and anticancer activity of novel quinazolinone-based rhodanines", Springer, 2017 More

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