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A novel membrane sensor for histamine H1-receptor antagonist ``fexofenadine{''
Faculty
Science
Year:
2004
Type of Publication:
Article
Pages:
1137-1142
Authors:
Fattah, AAA, Abbas, MN, Zahran, E
DOI:
10.2116/analsci.20.1137
Journal:
ANALYTICAL SCIENCES JAPAN SOC ANALYTICAL CHEMISTRY
Volume:
20
Research Area:
Chemistry
ISSN
ISI:000223281900005
Keywords :
, novel membrane sensor , histamine H1-receptor antagonist
Abstract:
The construction and general performance of thirteen new polymeric membrane sensors for the determination of fexofenadine hydrochloride based on its ion exchange with reineckate, tetraphenylborate and tetraiodomercurate have been studied. The effects of membrane composition, type of plasticizer, pH value of sample solution and concentration of the analyte in the sensor internal solution have been thoroughly investigated. The novel sensor based on reineckate exchanger shows a stable, potentiometric response for fexofenadine in the concentration range of 1 x 10(-2) - 2.5 x 10(-6) M at 25degreesC that is independent of pH in the range of 2.0 - 4.5. The sensor possesses a Nernstian cationic slope of 62.3 +/- 0.7 mV/concentration decade and a lower detection limit of 1.3 x 10(-6) M with a fast response time of 20 - 40 s. Selectivity coefficients for a number of interfering ions and excipients relative to fexofenadine were investigated. There is negligible interference from almost all studied cations, anions, and pharmaceutical excipients, however, citrizine that has a structure homologous to that of fexofenadine was found to interfere. The determination of fexofenadine in aqueous solution shows an average recovery of 99.83\% with a mean relative standard deviation (RSD) of 0.5\%. Direct potentiometric determination of fexofenadine in tablets gave results that compare favorably with those obtained by standard spectrophotometric methods. Potentiometric titration of fexofenadine with phosphomolybdic acid as a titrant has been monitored with the proposed sensor as an end point indicator electrode.
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