Extracellular α-synuclein induces sphingosine 1-phosphate receptor subtype 1 uncoupled from inhibitory G-protein leaving β-arrestin signal intact.

Faculty Agriculture Year: 2017
Type of Publication: ZU Hosted Pages:
Authors:
Shaimaa Mohamed Mohamed Badawi
Journal: Nature Scientific Reports Nature Scientific Reports Volume:
Keywords : Extracellular α-synuclein induces sphingosine 1-phosphate receptor    
Abstract:
Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder. The presence of α-synuclein (α-Syn)-positive intracytoplasmic inclusions, known as Lewy bodies, is the cytopathological hallmark of PD. Increasing bodi
    
     
 
       

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  • Shaimaa Mohamed Mohamed Badawi, "Extracellular α-synuclein drives sphingosine 1-phosphate receptor subtype 1 out of lipid rafts, leading to impaired inhibitory G-protein signaling.", Journal of Biological Chemistry, 2018 More
  • Shaimaa Mohamed Mohamed Badawi, "Involvement of Gβγ subunits of Gi protein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes.", Journal of Biological Chemistry, 2018 More
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  • Shaimaa Mohamed Mohamed Badawi, "Phospholipase D is Dispensable for Epidermal Growth Factor-Induced Chemotaxis.", Journal of Medical Science, 2017 More

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