Extracellular α-synuclein drives sphingosine 1-phosphate receptor subtype 1 out of lipid rafts, leading to impaired inhibitory G-protein signaling.

Faculty Agriculture Year: 2018
Type of Publication: ZU Hosted Pages:
Authors:
Shaimaa Mohamed Mohamed Badawi
Journal: Journal of Biological Chemistry Journal of Biological Chemistry Volume:
Keywords : Extracellular α-synuclein drives sphingosine 1-phosphate receptor    
Abstract:
Abstract α-Synuclein (α-Syn)-positive intracytoplasmic inclusions, known as Lewy bodies, are thought to be involved in the pathogenesis of Lewy body diseases, such as Parkinson's disease (PD). Although growing evidence suggests that cell-t
    
     
 
       

Author Related Publications

  • Shaimaa Mohamed Mohamed Badawi, "DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling.", Nature Science Reports, 2017 More
  • Shaimaa Mohamed Mohamed Badawi, "Involvement of Gβγ subunits of Gi protein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes.", Journal of Biological Chemistry, 2018 More
  • Shaimaa Mohamed Mohamed Badawi, "Extracellular α-synuclein induces sphingosine 1-phosphate receptor subtype 1 uncoupled from inhibitory G-protein leaving β-arrestin signal intact.", Nature Scientific Reports, 2017 More
  • Shaimaa Mohamed Mohamed Badawi, "Impairment of PDGF-induced chemotaxis by extracellular α-synuclein through selective inhibition of Rac1 activation.", Nature Scientific Reports, 2016 More
  • Shaimaa Mohamed Mohamed Badawi, "Phospholipase D is Dispensable for Epidermal Growth Factor-Induced Chemotaxis.", Journal of Medical Science, 2017 More

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