| Journal: |
NUCLEOSIDES NUCLEOTIDES \& NUCLEIC ACIDS
TAYLOR \& FRANCIS INC
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Volume: |
24
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| Keywords : |
L-tartaric acid, ethane, 1, 2-diol, 1, 2, 4-triazolo-[3, 4-b][1, 3, 4]-thiadiazine, 1, 2, 4-triazolo[3, 4-b][1, 3, 4] thiadiazole, acyclonucleoside
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| Abstract: |
Reaction of L-tartaric acid with thiocarbohydrazide afforded (1 R , 2 S )-1,2- bis (4-amino-5-mercapto-1,2,4-triazol-3-yl)-ethane-1,2-diol (3). The functional groups in 3 allowed the construction of fused heterocycles on the 1,2,4-triazole rings, mainly of the 1,2,4-triazolo{[}3,4- b ]{[}1,3,4]thiadiazine type as in 4, 5, 7, 10, 13 and 1,2,4-triazolo{[}3,4- b ]{[}1,3,4]thiadiazole type as in 14.
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