Synthesis of 3-benzylxanthine and lumazine analogues

Faculty Science Year: 2005
Type of Publication: Article Pages: 262-266
Authors:
YOUSSIF, S, El Ashry, ESH, El Ahwany, M, El Sanan, M
Journal: JOURNAL OF CHEMICAL RESEARCH-S SCIENCE REVIEWS LTD Volume:
Research Area: Chemistry ISSN ISI:000229953200018
Keywords : uracils, xanthines, lumazines, fused 1, 2, 3-triazoles, fused pyrimidines    
Abstract:
Several xanthines (7-13) are prepared by the cyclisation of 1-benzyl-5,6-diaminouracil with single-carbon inserting agents such as aromatic aldehydes, formamides, acetic anhydride, carbon disulfide, and nitrous acid. Treatment of 6-amino-1-benzyl-5-nitrosouracil with anilinobenzylidene derivatives (14-18) affords 7-hydroxyxanthines (19-23). Cyclisation of the diaminouracil 3 with glyoxal, benzil, and diethyl oxalate leads to lumazines (25-28).
    
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