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Extractive spectrophotometric methods for the determination of oxomemazine hydrochloride in bulk and pharmaceutical formulations using bromocresol green, bromocresol purple and bromophenol blue
Faculty
Science
Year:
2005
Type of Publication:
Article
Pages:
190-197
Authors:
El-Didamony, AM
DOI:
10.1002/ardp.200400947
Journal:
ARCHIV DER PHARMAZIE WILEY-V C H VERLAG GMBH
Volume:
338
Research Area:
Pharmacology \& Pharmacy; Chemistry
ISSN
ISI:000229343100006
Keywords :
oxomemazine HCl, extraction-spectrophotometry, ion-pair complexes, pharmaceutical formulations
Abstract:
Three simple, sensitive and accurate spectrophotometric methods have been developed for the determination of oxomemazine hydrochloride in bulk and pharmaceutical formulations. These methods are based on the formation of yellow ion-pair complexes between the examined drug and bromocresol green (BCG), bromocresol purple (BCP), and bromophenol blue (BPB) as sulphophthalein dyes in acetate-HCl buffer of pH 3.6, 3.4, and 4.0, respectively. The formed complexes were extracted with dichloromethane and measured at 405 nm for all three systems. The best conditions of the reactions were studied and optimized. Beer's law was obeyed in the concentration ranges 2.0-12, 2.0-13. and 2.0-14 mu g mL(-1) with molar absorptivities of 3.2 x 10(4), 3.7 x 10(4), and 3.1 x 10(4) L mol (1) cm(-1) for the BCG, BCP, and BPB methods. respectively. Sandell's sensitivity, correlation coefficient, detection and quantification limits are also calculated. The proposed methods have been applied successfully for the analysis of the drug in pure form and in its dosage forms. No interference was observed from common pharmaceutical excipients. Statistical comparison of the results with those obtained by H PLC method shows excellent agreement and indicates no significant difference in accuracy and precision.
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