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Indirect spectrophotometric determination of diltiazem hydrochloride in pure form and pharmaceutical formulations
Faculty
Science
Year:
2005
Type of Publication:
Article
Pages:
520-536
Authors:
El-Didamony, AM
DOI:
10.2478/BF02479280
Journal:
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY CENTRAL EUROPEAN SCIENCE JOURNALS
Volume:
3
Research Area:
Chemistry
ISSN
ISI:000230619800013
Keywords :
spectrophotometry, Diltiazem HCl, oxidation reaction, N-bromosuccinimide, cerric ammonium sulfate, pharmaceutical formulations
Abstract:
Three simple, accurate, and sensitive spectrophotometric methods (A, B and C) have been described for the indirect assay of diltiazem hydrochloride (DIL center dot HCl), either in pure form or in pharmaceutical formulations. The first method (A) is based on the oxidation of DIL center dot HCl by N-bromosuccinimide (NBS) and determination of unconsumed NBS by measuring the decrease in absorbance of amaranth dye (AM) at a suitable lambda(max) = 521 nm. Other methods (B) and (C) involve the addition of excess cerric ammonium sulfate (CAS) and subsequent determination of the unconsumed oxidant by a decrease in the red color of chromotrope 2R (C2R) at a suitable lambda(max) = 528 nm or a decrease in the orange-pink color of rhodamine 6G (Rh6G) at lambda(max) = 525 nm, respectively. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges 3.0 - 9.0, 3.5 - 7.0 and 3.5 - 6.3 mu g ml(-1) for methods A, B and C, respectively. The apparent molar absorptivity, Sandell's sensitivity, detection and quantification limits were calculated. The proposed methods have been applied successfully for the analysis of the drug in its pure form and its dosage form. No interference was observed from a common pharmaceutical adjuvant. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision. (C) Central European Science Journals. All rights reserved.
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