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Iron(II)-phthalocyanine as a novel recognition sensor for selective potentiometric determination of diclofenac and warfarin drugs
Faculty
Science
Year:
2005
Type of Publication:
Article
Pages:
315-321
Authors:
HASSAN, SSM, Elmosallamy, MAF, Mahmoud, WH, Almarzooqi, MH
DOI:
10.1016/j.jpba.2005.03.027
Journal:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS PERGAMON-ELSEVIER SCIENCE LTD
Volume:
39
Research Area:
Chemistry; Pharmacology \& Pharmacy
ISSN
ISI:000232209600045
Keywords :
iron(II)-phthalocyanine, lipophilic additives, potentiometry, pharmaceutical analysis, diclofenac, warfarin, PVC membrane sensors
Abstract:
Construction and characterization of potentiometric membrane sensors for quantification of diclofenac and warfarin drugs are described. The membranes of the sensors incorporate 1.8 wt.\% iron(II)-phthalocyanine (Pc) as a molecular recognition reagent, 64.3 wt.\% dibutylsebacate (DBS) solvent mediator, 1.8 wt.\% tridodecylmethylammonium chloride (TDMAC) as membrane additive and 32.1 wt.\% poly(vinyl chloride) (PVC) as a matrix. The sensors display linear response for 1 x 10(-2) to 9 X 10(-6) mol l(-1) (detection limit 5.4 x 10(-6) mol l(-1)) and 1 x 10(-2) to 5 x 10(-6) mol l(-1) (detection limit 3 x 10(-6) mol l(-1)) with anionic slopes of -61 +/- 1 and -63 +/- 1 mV decade(-1) over the pH range 5.5-9 for declofenac and warfarin, respectively. Validation of the assay methods according to the quality assurance standards confirms their suitability for quality control purposes. Use of the sensor for the assay of various formulations of the drugs shows a mean average recovery of 99.7\% of the nominal values and a mean precision of 10.3\%. Significantly improved accuracy, precision, response time, stability, selectivity and sensitivity are offered by these simple and cost-effective potentiometric sensors compared with other standard techniques. (c) 2005 Elsevier B.V. All rights reserved.
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