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Association of endothelial nitric oxide synthase gene polymorphisms with classical risk factors in development of premature coronary artery disease
Faculty
Medicine
Year:
2013
Type of Publication:
Article
Pages:
3065-3071
Authors:
Mohamed, R. H, Abdel-Aziz, T. A
DOI:
10.1007/s11033-012-2380-7
Journal:
MOLECULAR BIOLOGY REPORTS SPRINGER
Volume:
40
Research Area:
Biochemistry \& Molecular Biology
ISSN
ISI:000316221100034
Keywords :
eNOS, Genetic polymorphism, Premature CAD
Abstract:
Genetic polymorphism of the endothelial nitric oxide synthase (eNOS) affects the pathogenesis of atherosclerosis and associated with premature coronary artery disease (PCAD). We aimed to explore the association between Glu298Asp polymorphism of the eNOS gene and premature CAD in Egyptians, and the possible interaction between this polymorphism and other risk factors. The study population consisted of 116 patients with PCAD, and 119 controls. Glu298Asp polymorphism (rs1799983) of the eNOS gene was analyzed by polymerase chain reaction (PCR). We found that the TT genotype of the eNOS gene increased the risk of PCAD by 2.6. Hypertension, diabetes, smoking, total cholesterol, triglycerides, LDLc, HDLc and TT genotype of the eNOS gene were independent risk factors for the development of PCAD. We conclude that, the TT genotype of Glu298Asp polymorphism of eNOS gene is an independent risk factor of PCAD in Egyptians. The association of smoking, obesity, dyslipidemia and/or metabolic syndrome with the TT genotype increased the risk of the development of PCAD.
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