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Effect of nitazoxanide in diarrhea and enteritis caused by Cryptosporidium species
Faculty
Medicine
Year:
2006
Type of Publication:
Article
Pages:
320-324
Authors:
Rossignol, JF, Kabil, SM, El-Gohary, Y, Younis, AM
DOI:
10.1016/j.cgh.2005.12.020
Journal:
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY ELSEVIER SCIENCE INC
Volume:
4
Research Area:
Gastroenterology \& Hepatology
ISSN
ISI:000236096700013
Keywords :
Effect , nitazoxanide , diarrhea , enteritis caused , Cryptosporidium
Abstract:
Background \& Aims: The aim of this study was to evaluate the efficacy of nitazoxanide for the treatment of diarrhea and enteritis caused by Cryptosporidium species in patients 12 years of age and older. Methods: A multicenter, randomized, double-blind, placebo-controlled study was conducted in 90 outpatients 12 years of age and older from the Nile Delta region of Egypt. Patients were randomized to receive either one 500 mg tablet or one matching placebo tablet, or 25 mL of nitazoxanide oral suspension (500 mg nitazoxanide), each given twice daily for 3 days. Clinical and microbiologic response rates were evaluated 4 days after completion of treatment. Results: Twenty-seven (96\%) of the 28 patients receiving nitazoxanide tablets responded clinically compared with 11 (41\%) of 27 patients who received placebo (P <.0001). Twenty-six (93\%) of the 28 patients who received nitazoxanide were free of Cryptosporidium oocysts in each of 2 posttreatment stool samples compared with only 10 (37\%) of 27 patients who received placebo (P <.0001). Response rates in patients receiving the tablets and the suspension were comparable (clinical response rate for suspension, 27 of 31 {[}87\%]; microbiologic response rate for suspension, 28 of 31 {[}90\%]). Conclusions: These findings show that a 3-day course of nitazoxanide is effective in treating diarrhea and enteritis caused by Cryptosporidium in nonimmunodeficient patients 12 years of age and older.
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