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Spectrophotometric and spectrofluorimetric methods for analysis of acyclovir and acebutolol hydrochloride
Faculty
Pharmacy
Year:
2007
Type of Publication:
Article
Pages:
106-110
Authors:
Abdellatef, Hisham E, Ayad, Magda M, El-Henawee, Magda M, El-Sayed, Heba M
DOI:
10.1016/j.saa.2006.02.031
Journal:
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY PERGAMON-ELSEVIER SCIENCE LTD
Volume:
66
Research Area:
Spectroscopy
ISSN
ISI:000243159300018
Keywords :
Spectrophotometric , spectrofluorimetric methods , analysis , acyclovir , acebutolol
Abstract:
Simple and sensitive spectrophotometric and spectrofluorimetric methods are described for analysis of acyclovir and acebutolol hydrochloride. The proposed methods are based on oxidation of the selected drugs with cerium(IV) ion in acidic medium with subsequent measurement of either the decrease in absorbance at 320 nm or the fluorescence intensity of the produced cerous(III) ion at 361-363 nm (excitation at 250 nm). Beer's law obeyed from 2 to 8, 0.25 to 2.5 mu g cm(-1) acyclovir, 1 to 7 and 0.25 to 2.5 mu g ml(-1) acebutolol hydrochloride, using the spectrophotometric and spectrofluorimetric method, respectively. The proposed method were successfully applied for determination of the selected drugs in their pharmaceutical preparations with good recoveries. (c) 2006 Published by Elsevier B.V.
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