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A novel synthesis of some new pyrimidine and thiazolopyrimidine derivatives for anticancer evaluation
Faculty
Science
Year:
2007
Type of Publication:
Article
Pages:
1739-1756
Authors:
El-Farargy, A. F, Flefel, E. E, Salama, M. A, El-Shahat, M, El-Hashash, M. A
DOI:
10.1080/10426500701313912
Journal:
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS TAYLOR \& FRANCIS LTD
Volume:
182
Research Area:
Chemistry
ISSN
ISI:000247965400008
Keywords :
1, 3-diaryl-prop-2-en-1-ones, 1, 3-diaryl-2, 3-epoxypropanones, 4, 6-diaryl-hexahydro2-thioxopyrimidin-5-ones, anticancer and antimicrobial activity
Abstract:
Diaryl-oxiran-2-yl methanones ( 2) were prepared and reacted with thiourea to give 2-thioxo-tetrahydro-pyrimidine-5(2H)-ones ( 3). The latter compounds reacted with bromoacetic acid to afford the title compounds ( 4). Also some new derivatives were prepared from the reaction of compounds ( 3) and ( 4) with different reagents. Compounds ( 3) were glycosidated with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosylbromide (alpha-ABG) to afford the corresponding nucleosides.
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