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Anticytomegaloviral activity of esterified milk proteins and L-polylysines
Faculty
Agriculture
Year:
2007
Type of Publication:
Article
Pages:
255-258
Authors:
Sitohy, Mahmoud, Chobert, Jean-Marc, Haertle, Thomas, Billaudel, Sylviane, Dalgalarrondo, Michele
DOI:
10.1159/000104755
Journal:
JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY KARGER
Volume:
13
Research Area:
Biotechnology \& Applied Microbiology; Microbiology
ISSN
ISI:000249318200010
Keywords :
cytomegalovirus, esterification, milk, proteins, peptic peptides, polylysines, antiviral activity
Abstract:
MRC-5 fibroblasts infected with human cytomegalovirus (HCMV) reference strain AD 169 were treated with different concentrations of methylated alpha-lactalbumin (Met-ALA) or methylated alpha-lactoglobulin (Met-BLG), as well as with their peptic hydrolysates, and with the highly basic polypeptides such as are L-polylysines (4-15 kDa). The antiviral activity was calculated by comparing the number of infected cells in the presence and absence of the tested substances. Both MetALA and Met-BLG, as well as their peptic hydrolysates, decreased the infectious activity of cytomegalovirus in fibroblast cells. As expected, L-polylysines showed the highest antiviral activity. However, the tested basic proteins and polypeptides despite their lower antiviral activities might be potentially quite useful in fight of arising drug resistance activities and the persistence capacities of this virus. Copyright (c) 2007 S. Karger AG, Basel.
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