Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2- amines as Bcl-2 inhibitory anticancer agents

Faculty Pharmacy Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Alsayed Mohamed Mansour Lashen
Journal: Bioorganic & Medicinal Chemistry Letters Elsevier Volume:
Keywords : Synthesis , evaluation , 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2- amines , Bcl-2 inhibitory anticancer    
Abstract:
A series of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines 8a–j has been designed, synthesized and tested in vitro as potential pro-apoptotic Bcl-2-inhibitory anticancer agents based on our previous lead compound 8a. Synthesis of the t
    
     
 
       

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  • Alsayed Mohamed Mansour Lashen , "Targeting methionyl t RNA synthetase: design ,synthesis and antibacterial activity against clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", Journal of Enzyme Inhibition and Medicinal Chemistry, 2016 More
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