Non-carboxylic, analogues of arylpropionic acids: Synthesis, anti-inflammatory activity and ulcerogenic potential

Two series of 1,2,4-triazoles and 1,2,4-triazolo{[}3,4-b]-1,3,4-thiadiazoles derived from three selected arylpropionic acids namely, ibuprofen, flurbiprofen and naproxen, were synthesized and evaluated for anti-inflammatory activity and ulcerogenic potential. All the tested compounds exhibited anti-inflammatory activity comparable to that of hydrocortisone. Compared to ibuprofen, however, all the tested compounds displayed more potent anti-inflammatory activity. Compounds tested for ulcerogenicity showed no or minimal u1cerogenic effect compared to indomethacin. (c) 2006 Elsevier Masson SAS. All rights reserved.