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Pepsin assay: A marker for reflux in pediatric glue ear
Faculty
Medicine
Year:
2007
Type of Publication:
Article
Pages:
464-470
Authors:
Abd El-Fattah, Ahmed M, Maksoud, Gamal A. Abdul, Ramadan, Ahmed S, Abdalla, Ahmed F, Aziz, Mohamed M. Abdel
DOI:
10.1016/j.otohns.2006.08.030
Journal:
OTOLARYNGOLOGY-HEAD AND NECK SURGERY MOSBY-ELSEVIER
Volume:
136
Research Area:
Otorhinolaryngology; Surgery
ISSN
ISI:000244793200024
Keywords :
Pepsin assay: , marker , reflux , pediatric glue
Abstract:
OBJECTIVE: To evaluate if analysis of pepsin/pepsinogen in middle ear effusions can be considered a diagnostic marker for laryngopharyngeal reflux (LPR) in children with otitis media with effusion (OME). MATERIAL AND METHODS: Ambulatory 24-hour dual-probe pH monitoring was carried out on 31 children with OME. Middle ear effusions were collected from 17 children during myringotomy. Total pepsin/pepsinogen concentrations in effusions were measured by ELISA using antipepsin antibody. RESULTS: Dual-probe pH monitoring showed that 22/31 (71\%) of the studied children had significant LPR. The concentrations of pepsin/pepsinogen in middle ear effusions, ranged from 0.085 to 5.02 mu g/ml, were found to be up to 4.5 to 231.44 times higher than the serum levels. There was a significant positive correlation between the level of pepsin/pepsinogen assayed in the effusions of the 17 children and the number of pharyngeal reflux episodes measured by pH monitoring, CONCLUSIONS: Control of LPR may be an essential component in the successful management of OME in pediatric patients. Pepsin/pepsinogen analysis in effusions of children, using ELISA, can be considered a reliable marker for assessment of reflux in children with OME. (c) 2007 American Academy of Otolaryn-ology-Head and Neck Surgery Foundation. All rights reserved.
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