Synthesis, Anticonvulsant Activity, and SAR Study of Novel 4-Quinazolinone Derivatives

Faculty Pharmacy Year: 2017
Type of Publication: ZU Hosted Pages:
Authors:
Nada Abdasattar mohamed Noureddine
Journal: Archiv der Pharmazie Wiley Volume:
Keywords : Synthesis, Anticonvulsant Activity, , , Study , Novel 4-Quinazolinone Derivatives    
Abstract:
Series of N-(4-substitutedphenyl)-4-(1-methyl (or 1,2-dimethyl)-4-oxo-1,2-dihydroquinazolin-3(4H)-yl)-alkanamides (5a–j) and 4-chloro-N0-((1-methyl (or 1,2-dimethyl)-4-oxo-1,2-dihydroquinazolin-3(4H)-yl)alkaloyl)benzohydrazides (6a–f) were
   
     
 
       

Author Related Publications

  • Nada Abdasattar mohamed Noureddine, "Design, synthesis and biological evaluation of novel quinazoline-2,4- diones conjugated with different amino acids as potential chitin synthase inhibitors", elsevier, 2018 More
  • Nada Abdasattar mohamed Noureddine, "Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues", springer nature, 2021 More
  • Nada Abdasattar mohamed Noureddine, "Exploring Proteus mirabilis Methionine tRNA Synthetase Active Site: Homology Model Construction, Molecular Dynamics, Pharmacophore and Docking Validation", MDPI, 2023 More
  • Nada Abdasattar mohamed Noureddine, "Phenylalanyl tRNA synthetase (PheRS) substrate mimics: design, synthesis, molecular dynamics and antimicrobial evaluation", Royal Society of Chemistry, 2022 More
  • Nada Abdasattar mohamed Noureddine, "Inhibition of metallo-β-lactamases in carbapenem resistant Gram negative bacilli by omeprazole and pantoprazole", Makerere University Medical School, 2025 More

Department Related Publications

  • Mahmoud Mohamed Mohamed Sebaee, "Rapid RP-HPLC Method for Simultaneous Estimation of Some Antidiabetics; Metformin, Gliclazide and Glimepiride in Tablets", ejchem.journals.ekb.eg, 2018 More
  • Kamel Abdelrehem Metwaly Bayomy, "Pyrimido[4,5-c]quinolin-1(2H)-ones as a novel class of antimitotic agents: synthesis and in vitro cytotoxic activity", Elsevier, 2007 More
  • Kamel Abdelrehem Metwaly Bayomy, "Hydrazones of 2-arylquinoline-4-carboxylic acid hydrazides: synthesis and preliminary evaluation as antimicrobial agents", Elsevier, 2006 More
  • Samar Saied Mahmoud Mohamed Elbaramawy, "Design, synthesis, in vitro and in silico evaluation of novel substituted 1,2,4-triazole analogues as dual human VEGFR-2 and TB-InhA inhibitors", ELSEVIER, 2023 More
Tweet