Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study

Faculty Pharmacy Year: 2017
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Bioorganic & Medicinal Chemistry Letters ELSEVIER Volume:
Keywords : Quinazolinone-based rhodanine-3-acetic acids , potent aldose reductase    
Abstract:
A series of quinazolinone-based rhodanine-3-acetic acids was synthesized and tested for in vitro aldose reductase inhibitory activity. All the target compounds displayed nanomolar activity against the target enzyme. Compounds 3a, 3b, and 3e
    
     
 
       

Author Related Publications

    Department Related Publications

    • Alsayed Mohamed Mansour Lashen , "Synthesisis Of Certain Condensed Pyrimidines", لايوجد, 1900 More
    • Hassan Mohamed Kamal Mohamed Abozied Shalal, "Synthesis of some New Fused Heterocyclic Compounds for Biological Study", لايوجد, 1900 More
    • Rania Hamdy Ahmed Badawi, " Synthesis Of Novel 2-Sbstituted Quinaline -4-Carboxylic Acid Derivatives For Potential Biological Activity", لايوجد, 1900 More
    • Samy Megahed Ibrahiem Elsayed Sakr, "Synthesis Of Certain -4-Quinazolones Likely To Possess Pharmacological Activity", لايوجد, 1900 More
    • Samy Megahed Ibrahiem Elsayed Sakr, "ٍSynthesis And Biological Activity Of Some Novel Heterocyclic Compounds Containing Sulphar Of Pharmaceutical Interest ", لايوجد, 1900 More
    Tweet